Ready Boost is a disk caching technology that kicks in when you attach USB flash drives. This optimizes your system performance and is should be automatically switched on if you’re short on system memory and want to use a flash drive.
However, no software is that intelligent, and in some cases this feature is not enabled automatically. A registry hack can, however change the way Vista deploys this feature. Proceed at your own risk. In order to make ready boost default..
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Go to Start > My Computer > Right click on device > Properties > Ready Boost.
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Select Stop retesting the device when I plug it in.
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Remove the device.
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Open the registry editor Start > type regedit in the search box.
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Navigate to HKEY_LOCAL_MACHINE/SOFTWARE/Microsoft/Windows-NT/CurrentVersion/EMDgmt and change these registry values: Device Status to 2, ReadSpeedKBs to 1000 and WriteSpeedKBs to 1000.
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Restart the machine, and Ready Boost should be enabled every time.